Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction

RATIONALE: The beta-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to proteins is a pro-adaptive response to cellular insults. To this end, increased protein O-GlcNAcylation improves short-term survival of cardiomyocytes subjected to acute injury. This observation has been repeated by multiple gr...

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Veröffentlicht in:PLoS One
Hauptverfasser: Dassanayaka, Sujith, Brittian, Kenneth R., Long, Bethany W., Higgins, Lauren A., Bradley, James A., Audam, Timothy N., Jurkovic, Andrea, Gumpert, Anna M., Harrison, Linda T., Hartyánszky, István, Perge, Péter, Merkely, Béla, Radovits, Tamás, Hanover, John A., Jones, Steven P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703924/
https://ncbi.nlm.nih.gov/pubmed/33253217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0242250
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