Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes

BACKGROUND: The inhibitory functions triggered by the programmed cell death-1 (PD-1) receptor following binding to its ligand (PD-L1) protect healthy organs from cytotoxic T cells, and neutralize antitumor T cell attack. Antibody-based therapies to block PD-1/PD-L1 interaction have yielded notable r...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Arranz-Nicolás, Javier, Martin-Salgado, Miguel, Rodríguez-Rodríguez, Cristina, Liébana, Rosa, Moreno-Ortiz, Maria C, Leitner, Judith, Steinberger, Peter, Ávila-Flores, Antonia, Merida, Isabel
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Immune Cell Therapies and Immune Cell Engineering
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703416/
https://ncbi.nlm.nih.gov/pubmed/33246984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001521
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