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Diacylglycerol Kinase ζ Limits Cytokine-dependent Expansion of CD8(+) T Cells with Broad Antitumor Capacity
Interleukin-2 and -15 drive expansion/differentiation of cytotoxic CD8(+) T cells that eliminate targets via antigen-independent killing. This property is clinically relevant for the improvement of T cell-based antitumor therapies. Diacylglycerol kinase α and ζ (DGKα/ζ) metabolize the diacylglycerol...
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| Publicado no: | EBioMedicine |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5440620/ https://ncbi.nlm.nih.gov/pubmed/28438506 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2017.04.024 |
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