Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a

BACKGROUND AND AIMS: Glycogen storage disease (GSD) type 1a is an inborn error of metabolism caused by defective glucose‐6‐phosphatase catalytic subunit (G6PC) activity. Patients with GSD 1a exhibit severe hepatomegaly due to glycogen and triglyceride (TG) accumulation in the liver. We have shown th...

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Publicado no:Hepatology
Main Authors: Lei, Yu, Hoogerland, Joanne A., Bloks, Vincent W., Bos, Trijnie, Bleeker, Aycha, Wolters, Henk, Wolters, Justina C., Hijmans, Brenda S., van Dijk, Theo H., Thomas, Rachel, van Weeghel, Michel, Mithieux, Gilles, Houtkooper, Riekelt H., de Bruin, Alain, Rajas, Fabienne, Kuipers, Folkert, Oosterveer, Maaike H.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7702155/
https://ncbi.nlm.nih.gov/pubmed/32083759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.31198
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