Inhibition of IRE1/JNK pathway in HK‐2 cells subjected to hypoxia‐reoxygenation attenuates mesangial cells‐derived extracellular matrix production

Endoplasmic reticulum (ER) stress and inflammatory responses play active roles in the transition of acute kidney injury (AKI) to chronic kidney disease (CKD). Inositol‐requiring enzyme 1 (IRE1) activates c‐Jun NH(2)‐terminal kinase (JNK) in ER stress. Tubular epithelial cells (TEC) are the main inju...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Liang, Yan, Liang, Lulu, Liu, Zhenjie, Wang, Yingzi, Dong, Xiubing, Qu, Lingyun, Gou, Rong, Wang, Yulin, Wang, Qian, Liu, Zhangsuo, Tang, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7701502/
https://ncbi.nlm.nih.gov/pubmed/33043579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15964
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