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Employing chemical synthesis to study the structure and function of colibactin, a “dark matter” metabolite.
The classical discovery paradigm in the field of natural products follows the sequence of isolation, structure elucidation, chemical synthesis, and then elucidation of mechanism of action and structure–activity relationships. Although this discovery paradigm has proven successful in the past, resear...
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| Publicado en: | Nat Prod Rep |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7700718/ https://ncbi.nlm.nih.gov/pubmed/33174565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0np00072h |
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