(E)-1-(Furan-2-yl)-(substituted phenyl)prop-2-en-1-one Derivatives as Tyrosinase Inhibitors and Melanogenesis Inhibition: An In Vitro and In Silico Study

A series of (E)-1-(furan-2-yl)prop-2-en-1-one derivatives (compounds 1–8) were synthesized and evaluated for their mushroom tyrosinase inhibitory activity. Among these series, compound 8 (2,4-dihydroxy group bearing benzylidene) showed potent tyrosinase inhibitory activity, with respective IC(50) va...

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Publicado en:Molecules
Main Authors: Jung, Hee Jin, Noh, Sang Gyun, Ryu, Il Young, Park, Chaeun, Lee, Ji Young, Chun, Pusoon, Moon, Hyung Ryong, Chung, Hae Young
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7700175/
https://ncbi.nlm.nih.gov/pubmed/33233397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25225460
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