A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy

Antimicrobial peptides (AMPs) are a potential alternative to classical antibiotics that are yet to achieve a therapeutic breakthrough for treatment of systemic infections. The antibacterial potency of pleurocidin, an AMP from Winter Flounder, is linked to its ability to cross bacterial plasma membra...

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Publicado en:Commun Biol
Main Authors: Manzo, Giorgia, Hind, Charlotte K., Ferguson, Philip M., Amison, Richard T., Hodgson-Casson, Alice C., Ciazynska, Katarzyna A., Weller, Bethany J., Clarke, Maria, Lam, Carolyn, Man, Rico C. H., Shaughnessy, Blaze G. O’, Clifford, Melanie, Bui, Tam T., Drake, Alex F., Atkinson, R. Andrew, Lam, Jenny K. W., Pitchford, Simon C., Page, Clive P., Phoenix, David A., Lorenz, Christian D., Sutton, J. Mark, Mason, A. James
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7699649/
https://ncbi.nlm.nih.gov/pubmed/33247193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01420-3
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