A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy

Antimicrobial peptides (AMPs) are a potential alternative to classical antibiotics that are yet to achieve a therapeutic breakthrough for treatment of systemic infections. The antibacterial potency of pleurocidin, an AMP from Winter Flounder, is linked to its ability to cross bacterial plasma membra...

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Bibliografiset tiedot
Julkaisussa:Commun Biol
Päätekijät: Manzo, Giorgia, Hind, Charlotte K., Ferguson, Philip M., Amison, Richard T., Hodgson-Casson, Alice C., Ciazynska, Katarzyna A., Weller, Bethany J., Clarke, Maria, Lam, Carolyn, Man, Rico C. H., Shaughnessy, Blaze G. O’, Clifford, Melanie, Bui, Tam T., Drake, Alex F., Atkinson, R. Andrew, Lam, Jenny K. W., Pitchford, Simon C., Page, Clive P., Phoenix, David A., Lorenz, Christian D., Sutton, J. Mark, Mason, A. James
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7699649/
https://ncbi.nlm.nih.gov/pubmed/33247193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01420-3
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