Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity

Antimicrobial peptides (AMPs) are a potential source of new molecules to counter the increase in antimicrobial resistant infections but a better understanding of their properties is required to understand their native function and for effective translation as therapeutics. Details of the mechanism o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Manzo, Giorgia, Ferguson, Philip M., Gustilo, V. Benjamin, Hind, Charlotte K., Clifford, Melanie, Bui, Tam T., Drake, Alex F., Atkinson, R. Andrew, Sutton, J. Mark, Batoni, Giovanna, Lorenz, Christian D., Phoenix, David A., Mason, A. James
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362004/
https://ncbi.nlm.nih.gov/pubmed/30718667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37630-3
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