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Minor sequence modifications in temporin B cause drastic changes in antibacterial potency and selectivity by fundamentally altering membrane activity

Antimicrobial peptides (AMPs) are a potential source of new molecules to counter the increase in antimicrobial resistant infections but a better understanding of their properties is required to understand their native function and for effective translation as therapeutics. Details of the mechanism o...

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Dettagli Bibliografici
Pubblicato in:Sci Rep
Autori principali: Manzo, Giorgia, Ferguson, Philip M., Gustilo, V. Benjamin, Hind, Charlotte K., Clifford, Melanie, Bui, Tam T., Drake, Alex F., Atkinson, R. Andrew, Sutton, J. Mark, Batoni, Giovanna, Lorenz, Christian D., Phoenix, David A., Mason, A. James
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6362004/
https://ncbi.nlm.nih.gov/pubmed/30718667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37630-3
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