Acid Sphingomyelinase Impacts Canonical Transient Receptor Potential Channels 6 (TRPC6) Activity in Primary Neuronal Systems

The acid sphingomyelinase (ASM)/ceramide system exhibits a crucial role in the pathology of major depressive disorder (MDD). ASM hydrolyzes the abundant membrane lipid sphingomyelin to ceramide that regulates the clustering of membrane proteins via microdomain and lipid raft organization. Several co...

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Vydáno v:Cells
Hlavní autoři: Zeitler, Stefanie, Schumacher, Fabian, Monti, Juliana, Anni, Daniela, Guhathakurta, Debarpan, Kleuser, Burkhard, Friedland, Kristina, Fejtová, Anna, Kornhuber, Johannes, Rhein, Cosima
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7698877/
https://ncbi.nlm.nih.gov/pubmed/33218173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9112502
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