Fruquintinib inhibits VEGF/VEGFR2 axis of choroidal endothelial cells and M1-type macrophages to protect against mouse laser-induced choroidal neovascularization

Wet age-related macular degeneration, which is characterized by choroidal neovascularization (CNV) and induces obvious vision loss. Vascular endothelial growth factor (VEGF) family member VEGF-A (also named as VEGF) and its receptor VEGFR2 contribute to the pathogenesis of CNV. Choroidal endothelial...

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Vydáno v:Cell Death Dis
Hlavní autoři: Liu, Xiaojuan, Guo, Aisong, Tu, Yuanyuan, Li, Wendie, Li, Lele, Liu, Wangrui, Ju, Yuanyuan, Zhou, Yamei, Sang, Aimin, Zhu, Manhui
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7695853/
https://ncbi.nlm.nih.gov/pubmed/33247124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-03222-1
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