Mendelian randomization study shows no causal effects of serum urate levels on the risk of MS

OBJECTIVE: To examine whether lifelong genetically increased serum urate levels, a potent antioxidant, contribute to MS susceptibility using Mendelian randomization (MR). METHODS: This 2-sample MR study included 25 independent genetic variants strongly associated with serum urate levels in a genome-...

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Udgivet i:Neurol Neuroimmunol Neuroinflamm
Main Authors: Harroud, Adil, Richards, J. Brent, Baranzini, Sergio E.
Format: Artigo
Sprog:Inglês
Udgivet: Lippincott Williams & Wilkins 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7694579/
https://ncbi.nlm.nih.gov/pubmed/33214142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000920
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