Causal assessment of serum urate levels in cardiometabolic diseases through a Mendelian Randomization study

BACKGROUND: Although epidemiological studies have reported positive associations between circulating urate levels and cardiometabolic diseases, causality remains uncertain. OBJECTIVE: Through a Mendelian randomization approach, we assessed whether serum urate levels are causally relevant in type-2 d...

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Publicado en:J Am Coll Cardiol
Autores principales: Keenan, Tanya, Zhao, Wei, Rasheed, Asif, Ho, Weang K., Malik, Rainer, Felix, Janine F, Young, Robin, Shah, Nabi, Samuel, Maria, Sheikh, Nasir, Mucksavage, Megan L., Shah, Omar, Li, Jin, Morley, Michael, Laser, Annika, Mallick, Nadeem Hayat, Zaman, Khan Shah, Ishaq, Mohammad, Rasheed, Syed Zahed, Memon, Fazal-ur-Rehman, Ahmed, Faisal, Hanif, Bashir, Lakhani, Muhammad Shakir, Fahim, Muhammad, Ishaq, Madiha, Shardha, Naresh Kumar, Ahmed, Naveeduddin, Mahmood, Khalid, Iqbal, Waseem, Akhtar, Saba, Raheel, Rabia, O’Donnell, Christopher J., Hengstenberg, Christian, Marz, Winifred, Kathiresan, Sekar, Samani, Nilesh, Goel, Anuj, Hopewell, Jemma C, Chambers, John, Cheng, Yu-Ching, Sharma, Pankaj, Yang, Qiong, Rosand, Jonathan, Boncoraglio, Giorgio B., Kazmi, Shahana Urooj, Hakonarson, Hakon, Köttgen, Anna, Kalogeropoulos, Andreas, Frossard, Philippe, Kamal, Ayeesha, Dichgans, Martin, Cappola, Thomas, Reilly, Muredach P., Danesh, John, Rader, Daniel J., Voight, Benjamin F., Saleheen, Danish
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503188/
https://ncbi.nlm.nih.gov/pubmed/26821629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2015.10.086
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