Mendelian Randomization Study Shows No Causal Relationship Between Circulating Urate Levels and Parkinson’s Disease

OBJECTIVE: Observational studies have shown that increased plasma urate is associated with lower risk of Parkinson’s disease (PD), but these studies were not designed to test causality. If a causal relationship exists, then modulating plasma urate levels could be a potential preventive avenue for PD...

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Udgivet i:Ann Neurol
Main Authors: Kia, Demis A., Noyce, Alastair J., White, Jon, Speed, Doug, Nicolas, Aude, Burgess, Stephen, Lawlor, Debbie A., Smith, George Davey, Singleton, Andrew, Nalls, Mike A., Sofat, Reecha, Wood, Nicholas W.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6481555/
https://ncbi.nlm.nih.gov/pubmed/30014513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.25294
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