Astrocyte-derived clusterin suppresses amyloid formation in vivo

BACKGROUND: Accumulation of amyloid-β (Aβ) peptide in the brain is a pathological hallmark of Alzheimer’s disease (AD). The clusterin (CLU) gene confers a risk for AD and CLU is highly upregulated in AD patients, with the common non-coding, protective CLU variants associated with increased expressio...

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Udgivet i:Mol Neurodegener
Main Authors: Wojtas, Aleksandra M., Sens, Jonathon P., Kang, Silvia S., Baker, Kelsey E., Berry, Taylor J., Kurti, Aishe, Daughrity, Lillian, Jansen-West, Karen R., Dickson, Dennis W., Petrucelli, Leonard, Bu, Guojun, Liu, Chia-Chen, Fryer, John D.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7694353/
https://ncbi.nlm.nih.gov/pubmed/33246484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00416-1
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