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Astrocyte-derived clusterin suppresses amyloid formation in vivo
BACKGROUND: Accumulation of amyloid-β (Aβ) peptide in the brain is a pathological hallmark of Alzheimer’s disease (AD). The clusterin (CLU) gene confers a risk for AD and CLU is highly upregulated in AD patients, with the common non-coding, protective CLU variants associated with increased expressio...
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| Опубликовано в: : | Mol Neurodegener |
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| Главные авторы: | , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7694353/ https://ncbi.nlm.nih.gov/pubmed/33246484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00416-1 |
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