Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

Alzheimer’s disease (AD) is an age-associated neurodegenerative disease characterized by amyloidosis, tauopathy, and activation of microglia, the brain resident innate immune cells. We show that a RiboTag translational profiling approach can bypass biases due to cellular enrichment/cell sorting. Usi...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Kang, Silvia S., Ebbert, Mark T.W., Baker, Kelsey E., Cook, Casey, Wang, Xuewei, Sens, Jonathon P., Kocher, Jeanne-Pierre, Petrucelli, Leonard, Fryer, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122978/
https://ncbi.nlm.nih.gov/pubmed/30082275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180653
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