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Preparation and Evaluation of Amino Acid Conjugates of Celecoxib as Prodrugs to Improve the Pharmacokinetic and Therapeutic Properties of Celecoxib

Although celecoxib is quite effective in the management of inflammation-related diseases, especially arthritis, its use is limited by concerns including low bioavailability (BA), non-linear pharmacokinetic (PK) profile, and peak concentration-related toxicity. To overcome these issues, we designed a...

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Опубликовано в: :Pharmaceutics
Главные авторы: Lee, Yonghyun, Kim, Jungyun, Kim, Wooseong, Yoon, In-Soo, Jung, Yunjin
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7693880/
https://ncbi.nlm.nih.gov/pubmed/33143357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12111043
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