Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis

Compounds with novel modes of action are urgently needed to develop effective combination therapies for the treatment of tuberculosis. In this study, a series of compounds was evaluated for activity against replicating Mycobacterium tuberculosis and Vero cell line toxicity. Fourteen of the compounds...

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Bibliografiska uppgifter
I publikationen:Front Cell Infect Microbiol
Huvudupphovsmän: Chengalroyen, Melissa D., Jordaan, Audrey, Seldon, Ronnett, Ioerger, Thomas, Franzblau, Scott G., Nasr, Mohamed, Warner, Digby F., Mizrahi, Valerie
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2020
Ämnen:
Cellular and Infection Microbiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691319/
https://ncbi.nlm.nih.gov/pubmed/33282750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.582416
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