Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis

Compounds with novel modes of action are urgently needed to develop effective combination therapies for the treatment of tuberculosis. In this study, a series of compounds was evaluated for activity against replicating Mycobacterium tuberculosis and Vero cell line toxicity. Fourteen of the compounds...

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Publicado en:Front Cell Infect Microbiol
Autores principales: Chengalroyen, Melissa D., Jordaan, Audrey, Seldon, Ronnett, Ioerger, Thomas, Franzblau, Scott G., Nasr, Mohamed, Warner, Digby F., Mizrahi, Valerie
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2020
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691319/
https://ncbi.nlm.nih.gov/pubmed/33282750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.582416
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