Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis

Compounds with novel modes of action are urgently needed to develop effective combination therapies for the treatment of tuberculosis. In this study, a series of compounds was evaluated for activity against replicating Mycobacterium tuberculosis and Vero cell line toxicity. Fourteen of the compounds...

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Detalhes bibliográficos
Publicado no:Front Cell Infect Microbiol
Main Authors: Chengalroyen, Melissa D., Jordaan, Audrey, Seldon, Ronnett, Ioerger, Thomas, Franzblau, Scott G., Nasr, Mohamed, Warner, Digby F., Mizrahi, Valerie
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cellular and Infection Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691319/
https://ncbi.nlm.nih.gov/pubmed/33282750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.582416
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