Biological Profiling Enables Rapid Mechanistic Classification of Phenotypic Screening Hits and Identification of KatG Activation-Dependent Pyridine Carboxamide Prodrugs With Activity Against Mycobacterium tuberculosis

Compounds with novel modes of action are urgently needed to develop effective combination therapies for the treatment of tuberculosis. In this study, a series of compounds was evaluated for activity against replicating Mycobacterium tuberculosis and Vero cell line toxicity. Fourteen of the compounds...

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Pubblicato in:Front Cell Infect Microbiol
Autori principali: Chengalroyen, Melissa D., Jordaan, Audrey, Seldon, Ronnett, Ioerger, Thomas, Franzblau, Scott G., Nasr, Mohamed, Warner, Digby F., Mizrahi, Valerie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Cellular and Infection Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691319/
https://ncbi.nlm.nih.gov/pubmed/33282750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcimb.2020.582416
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