Activation of the mechanosensitive Ca(2+) channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics

Mechanical ventilation is a life-saving intervention in critically ill patients with respiratory failure due to acute respiratory distress syndrome (ARDS), a refractory lung disease with an unacceptable high mortality rate. Paradoxically, mechanical ventilation also creates excessive mechanical stre...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Lu, Qing, Zemskov, Evgeny A., Sun, Xutong, Wang, Hui, Yegambaram, Manivannan, Wu, Xiaomin, Garcia-Flores, Alejandro, Song, Shanshan, Tang, Haiyang, Kangath, Archana, Cabanillas, Gabriela Zubiate, Yuan, Jason X.-J., Wang, Ting, Fineman, Jeffrey R., Black, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691184/
https://ncbi.nlm.nih.gov/pubmed/33221570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101785
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