TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis

Transforming growth factor beta-1 (TGF-β1) signaling is increased and mitochondrial function is decreased in multiple models of pulmonary hypertension (PH) including lambs with increased pulmonary blood flow (PBF) and pressure (Shunt). However, the potential link between TGF-β1 and the loss of mitoc...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Sun, Xutong, Lu, Qing, Yegambaram, Manivannan, Kumar, Sanjiv, Qu, Ning, Srivastava, Anup, Wang, Ting, Fineman, Jeffrey R., Black, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303661/
https://ncbi.nlm.nih.gov/pubmed/32554303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101593
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