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TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis

Transforming growth factor beta-1 (TGF-β1) signaling is increased and mitochondrial function is decreased in multiple models of pulmonary hypertension (PH) including lambs with increased pulmonary blood flow (PBF) and pressure (Shunt). However, the potential link between TGF-β1 and the loss of mitoc...

詳細記述

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書誌詳細
出版年:Redox Biol
主要な著者: Sun, Xutong, Lu, Qing, Yegambaram, Manivannan, Kumar, Sanjiv, Qu, Ning, Srivastava, Anup, Wang, Ting, Fineman, Jeffrey R., Black, Stephen M.
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303661/
https://ncbi.nlm.nih.gov/pubmed/32554303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101593
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