TGF-β1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis

Transforming growth factor beta-1 (TGF-β1) signaling is increased and mitochondrial function is decreased in multiple models of pulmonary hypertension (PH) including lambs with increased pulmonary blood flow (PBF) and pressure (Shunt). However, the potential link between TGF-β1 and the loss of mitoc...

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Veröffentlicht in:Redox Biol
Hauptverfasser: Sun, Xutong, Lu, Qing, Yegambaram, Manivannan, Kumar, Sanjiv, Qu, Ning, Srivastava, Anup, Wang, Ting, Fineman, Jeffrey R., Black, Stephen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303661/
https://ncbi.nlm.nih.gov/pubmed/32554303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101593
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