CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis

P2X7 receptor activation induces the release of different cellular proteins, such as CD14, a glycosylphosphatidylinositol (GPI)-anchored protein to the plasma membrane important for LPS signaling via TLR4. Circulating CD14 has been found at elevated levels in sepsis, but the exact mechanism of CD14...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Alarcón-Vila, Cristina, Baroja-Mazo, Alberto, de Torre-Minguela, Carlos, Martínez, Carlos M, Martínez-García, Juan J, Martínez-Banaclocha, Helios, García-Palenciano, Carlos, Pelegrin, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Immunology and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7690950/
https://ncbi.nlm.nih.gov/pubmed/33135636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60849
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