P2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production

Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain as a soluble cytokine. The purinergic receptor...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Barberà-Cremades, Maria, Gómez, Ana I., Baroja-Mazo, Alberto, Martínez-Alarcón, Laura, Martínez, Carlos M., de Torre-Minguela, Carlos, Pelegrín, Pablo
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523084/
https://ncbi.nlm.nih.gov/pubmed/28791020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00862
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