Enhanced Water Solubility and Oral Bioavailability of Paclitaxel Crystal Powders through an Innovative Antisolvent Precipitation Process: Antisolvent Crystallization Using Ionic Liquids as Solvent

Paclitaxel (PTX) is a poor water-soluble antineoplastic drug with significant antitumor activity. However, its low bioavailability is a major obstacle for its biomedical applications. Thus, this experiment is designed to prepare PTX crystal powders through an antisolvent precipitation process using...

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Bibliographic Details
Published in:Pharmaceutics
Main Authors: Yang, Qilei, Zu, Chang, Li, Wengang, Wu, Weiwei, Ge, Yunlong, Wang, Lingling, Wang, Li, Li, Yong, Zhao, Xiuhua
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7690586/
https://ncbi.nlm.nih.gov/pubmed/33105832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12111008
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