Simvastatin Induces Unfolded Protein Response and Enhances Temozolomide-Induced Cell Death in Glioblastoma Cells

Glioblastoma (GBM) is the most prevalent malignant primary brain tumor with a very poor survival rate. Temozolomide (TMZ) is the common chemotherapeutic agent used for GBM treatment. We recently demonstrated that simvastatin (Simva) increases TMZ-induced apoptosis via the inhibition of autophagic fl...

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Udgivet i:Cells
Main Authors: Dastghaib, Sanaz, Shojaei, Shahla, Mostafavi-Pour, Zohreh, Sharma, Pawan, Patterson, John B., Samali, Afshin, Mokarram, Pooneh, Ghavami, Saeid
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7690447/
https://ncbi.nlm.nih.gov/pubmed/33105603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9112339
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