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‘Resistance is futile?’ – paradoxical inhibitory effects of K(ATP) channel closure in glucagon‐secreting α‐cells
By secreting insulin and glucagon, the β‐ and α‐cells of the pancreatic islets play a central role in the regulation of systemic metabolism. Both cells are equipped with ATP‐regulated potassium (K(ATP)) channels that are regulated by the intracellular ATP/ADP ratio. In β‐cells, K(ATP) channels are a...
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| Published in: | J Physiol |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
John Wiley and Sons Inc.
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7689873/ https://ncbi.nlm.nih.gov/pubmed/32716554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP279775 |
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