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‘Resistance is futile?’ – paradoxical inhibitory effects of K(ATP) channel closure in glucagon‐secreting α‐cells

By secreting insulin and glucagon, the β‐ and α‐cells of the pancreatic islets play a central role in the regulation of systemic metabolism. Both cells are equipped with ATP‐regulated potassium (K(ATP)) channels that are regulated by the intracellular ATP/ADP ratio. In β‐cells, K(ATP) channels are a...

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Dades bibliogràfiques
Publicat a:J Physiol
Autors principals: Zhang, Quan, Dou, Haiqiang, Rorsman, Patrik
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689873/
https://ncbi.nlm.nih.gov/pubmed/32716554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP279775
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