Non-canonical Shedding of TNFα by SPPL2a Is Determined by the Conformational Flexibility of Its Transmembrane Helix

Ectodomain (EC) shedding defines the proteolytic removal of a membrane protein EC and acts as an important molecular switch in signaling and other cellular processes. Using tumor necrosis factor (TNF)α as a model substrate, we identify a non-canonical shedding activity of SPPL2a, an intramembrane cl...

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Publicado en:iScience
Autores principales: Spitz, Charlotte, Schlosser, Christine, Guschtschin-Schmidt, Nadja, Stelzer, Walter, Menig, Simon, Götz, Alexander, Haug-Kröper, Martina, Scharnagl, Christina, Langosch, Dieter, Muhle-Goll, Claudia, Fluhrer, Regina
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689174/
https://ncbi.nlm.nih.gov/pubmed/33294784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101775
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