GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth

We report here that the autocrine signaling mediated by growth and differentiation factor 6 (GDF6), a member of the bone morphogenetic protein (BMP) family of cytokines, maintains Ewing sarcoma growth by preventing Src hyperactivation. Surprisingly, Ewing sarcoma depends on the prodomain, not the BM...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell Rep
Autori principali: Zhou, Fuchun, Elzi, David J., Jayabal, Panneerselvam, Ma, Xiuye, Chiu, Yu-Chiao, Chen, Yidong, Blackman, Barron, Weintraub, Susan T., Houghton, Peter J., Shiio, Yuzuru
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688343/
https://ncbi.nlm.nih.gov/pubmed/33147457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108332
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi