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Evaluation of [(131)I]I- and [(177)Lu]Lu-DTPA-A11 minibody for radioimmunotherapy in a preclinical model of PSCA-expressing prostate cancer
PURPOSE: Radioimmunotherapy uses tumor-specific antibodies to deliver therapeutic radionuclides, but hematological toxicity due to the long serum half-life of intact antibodies remains a challenge. We evaluated a smaller antibody fragment, the minibody, with faster kinetics and a potentially improve...
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| Publicado no: | Mol Imaging Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7688013/ https://ncbi.nlm.nih.gov/pubmed/32661830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11307-020-01518-4 |
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