Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation

BACKGROUND: Ex vivo production of hematopoietic stem/precursor cells (HSPCs) represents a promising versatile approach for blood disorders. METHODS: To derive definitive HSPCs from human embryonic stem cells (ESCs), we differentiated mesodermally specified embryoid bodies (EBs) on gelatin-coated pla...

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Bibliografiske detaljer
Udgivet i:Stem Cell Res Ther
Main Authors: Demirci, Selami, Haro-Mora, Juan J., Leonard, Alexis, Drysdale, Claire, Malide, Daniela, Keyvanfar, Keyvan, Essawi, Khaled, Vizcardo, Raul, Tamaoki, Naritaka, Restifo, Nicholas P., Tisdale, John F., Uchida, Naoya
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
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Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688003/
https://ncbi.nlm.nih.gov/pubmed/33234163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-02019-5
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