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Twinfilin bypasses assembly conditions and actin filament aging to drive barbed end depolymerization

Cellular actin networks grow by ATP-actin addition at filament barbed ends and have long been presumed to depolymerize at their pointed ends, primarily after filaments undergo “aging” (ATP hydrolysis and P(i) release). The cytosol contains high levels of actin monomers, which favors assembly over di...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Shekhar, Shashank, Hoeprich, Gregory J., Gelles, Jeff, Goode, Bruce L.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686915/
https://ncbi.nlm.nih.gov/pubmed/33226418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202006022
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