Combining T-cell–specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors

Genetic modification of T lymphocytes is a key issue in research and therapy. Conventional lentiviral vectors (LVs) are neither selective for T cells nor do they modify resting or minimally stimulated cells, which is crucial for applications, such as efficient in vivo modification of T lymphocytes....

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Frank, Annika M., Braun, Angela H., Scheib, Lea, Agarwal, Shiwani, Schneider, Irene C., Fusil, Floriane, Perian, Séverine, Sahin, Ugur, Thalheimer, Frederic B., Verhoeyen, Els, Buchholz, Christian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686896/
https://ncbi.nlm.nih.gov/pubmed/33216892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002229
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