Combining T-cell–specific activation and in vivo gene delivery through CD3-targeted lentiviral vectors

Genetic modification of T lymphocytes is a key issue in research and therapy. Conventional lentiviral vectors (LVs) are neither selective for T cells nor do they modify resting or minimally stimulated cells, which is crucial for applications, such as efficient in vivo modification of T lymphocytes....

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Blood Adv
Egile Nagusiak: Frank, Annika M., Braun, Angela H., Scheib, Lea, Agarwal, Shiwani, Schneider, Irene C., Fusil, Floriane, Perian, Séverine, Sahin, Ugur, Thalheimer, Frederic B., Verhoeyen, Els, Buchholz, Christian J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2020
Gaiak:
Gene Therapy
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686896/
https://ncbi.nlm.nih.gov/pubmed/33216892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020002229
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