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α-Synuclein promotes IAPP fibril formation in vitro and β-cell amyloid formation in vivo in mice
Type 2 diabetes (T2D), alike Parkinson’s disease (PD), belongs to the group of protein misfolding diseases (PMDs), which share aggregation of misfolded proteins as a hallmark. Although the major aggregating peptide in β-cells of T2D patients is Islet Amyloid Polypeptide (IAPP), alpha-synuclein (αSyn...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7686322/ https://ncbi.nlm.nih.gov/pubmed/33235246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77409-z |
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