PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients

AMPK activated protein kinase (AMPK), a master regulator of energy homeostasis, is activated in response to an energy shortage imposed by physical activity and caloric restriction. We here report on the identification of PAN-AMPK activator O304, which — in diet-induced obese mice — increased glucose...

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Publicat a:JCI Insight
Autors principals: Steneberg, Pär, Lindahl, Emma, Dahl, Ulf, Lidh, Emmelie, Straseviciene, Jurate, Backlund, Fredrik, Kjellkvist, Elisabet, Berggren, Eva, Lundberg, Ingela, Bergqvist, Ingela, Ericsson, Madelene, Eriksson, Björn, Linde, Kajsa, Westman, Jacob, Edlund, Thomas, Edlund, Helena
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6124394/
https://ncbi.nlm.nih.gov/pubmed/29925691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99114
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