HUWE1 mediates inflammasome activation and promotes host defense against bacterial infection

The mechanism by which inflammasome activation is modulated remains unclear. In this study, we identified an AIM2-interacting protein, the E3 ubiquitin ligase HUWE1, which was also found to interact with NLRP3 and NLRC4 through the HIN domain of AIM2 and the NACHT domains of NLRP3 and NLRC4. The BH3...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:J Clin Invest
Main Authors: Guo, Yu, Li, Longjun, Xu, Tao, Guo, Xiaomin, Wang, Chaoming, Li, Yihui, Yang, Yanan, Yang, Dong, Sun, Bin, Zhao, Xudong, Shao, Genze, Qi, Xiaopeng
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2020
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685759/
https://ncbi.nlm.nih.gov/pubmed/33104527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138234
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla