RNF220 mediates K63-linked polyubiquitination of STAT1 and promotes host defense

STAT1 is a master regulator that orchestrates type 1 and 2 interferon (IFN)-induced IFN-stimulated gene (ISG) expression. The mechanisms by which STAT1 is phosphorylated and activated upon IFN signaling remain elusive. Our work demonstrated that ubiquitination of STAT1 mediated by the E3 ligase RNF2...

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Pubblicato in:Cell Death Differ
Autori principali: Guo, Xiaomin, Ma, Pengcheng, Li, Yuwei, Yang, Yanan, Wang, Chaoming, Xu, Tao, Wang, Huishan, Li, Chaocui, Mao, Bingyu, Qi, Xiaopeng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862670/
https://ncbi.nlm.nih.gov/pubmed/32814877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00609-7
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