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Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration
The Spike protein of SARS-CoV-2, its receptor-binding domain (RBD), and its primary receptor ACE2 are extensively glycosylated. The impact of this post-translational modification on viral entry is yet unestablished. We expressed different glycoforms of the Spike-protein and ACE2 in CRISPR-Cas9 glyco...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7685702/ https://ncbi.nlm.nih.gov/pubmed/33103998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61552 |
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