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A 4-Base-Pair Core-Enclosing Helix in Telomerase RNA Is Essential for Activity and for Binding to the Telomerase Reverse Transcriptase Catalytic Protein Subunit

The telomerase ribonucleoprotein (RNP) counters the chromosome end replication problem, completing genome replication to prevent cellular senescence in yeast, humans, and most other eukaryotes. The telomerase RNP core enzyme is composed of a dedicated RNA subunit and a reverse transcriptase (telomer...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Mefford, Melissa A., Hass, Evan P., Zappulla, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685517/
https://ncbi.nlm.nih.gov/pubmed/33046533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00239-20
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