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Regulation of the Telomerase Reverse Transcriptase Subunit through Epigenetic Mechanisms

Chromosome-shortening is characteristic of normal cells, and is known as the end replication problem. Telomerase is the enzyme responsible for extending the ends of the chromosomes in de novo synthesis, and occurs in germ cells as well as most malignant cancers. There are three subunits of telomeras...

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Vydáno v:Front Genet
Hlavní autoři: Lewis, Kayla A., Tollefsbol, Trygve O.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860561/
https://ncbi.nlm.nih.gov/pubmed/27242892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2016.00083
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