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Radiosensitization effect of poly(ADP‐ribose) polymerase inhibition in cells exposed to low and high liner energy transfer radiation

Poly(ADP‐ribose) polymerase (PARP)‐1 promotes base excision repair and DNA strand break repair. Inhibitors of PARP enhance the cytotoxic effects of γ‐irradiation and X‐irradiation. We investigated the impact of PARP inhibition on the responses to γ‐irradiation (low liner energy transfer [LET] radiat...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Hirai, Takahisa, Shirai, Hidenori, Fujimori, Hiroaki, Okayasu, Ryuichi, Sasai, Keisuke, Masutani, Mitsuko
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685087/
https://ncbi.nlm.nih.gov/pubmed/22404155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02268.x
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