Inconsistent reversal of HIV-1 latency ex vivo by antigens of HIV-1, CMV, and other infectious agents

BACKGROUND: A reservoir of replication-competent but latent virus is the main obstacle to a cure for HIV-1 infection. Much of this reservoir resides in memory CD4 T cells. We hypothesized that these cells can be reactivated with antigens from HIV-1 and other common pathogens to reverse latency. RESU...

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Publicat a:Retrovirology
Autors principals: Vollbrecht, Thomas, Angerstein, Aaron O., Menke, Bryson, Kumar, Nikesh M., de Oliveira, Michelli Faria, Richman, Douglas D., Guatelli, John C.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7684880/
https://ncbi.nlm.nih.gov/pubmed/33228686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-020-00545-x
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