Mechanisms of resistance to CAR T cell therapies

Chimeric antigen receptor (CAR)-engineered T cells have demonstrated remarkable success in the treatment of B cell malignancies. FDA approval of these therapies represents a watershed moment in the development of therapies for cancer. Despite the successes of the last decade, many patients will unfo...

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Udgivet i:Semin Cancer Biol
Main Authors: Singh, Nathan, Orlando, Elena, Xu, Jun, Xu, Jie, Binder, Zev, Collins, McKensie A., O’Rourke, Donald M., Melenhorst, J. Joseph
Format: Artigo
Sprog:Inglês
Udgivet: 2019
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7684646/
https://ncbi.nlm.nih.gov/pubmed/31866478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcancer.2019.12.002
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