ETNK1 mutations induce a mutator phenotype that can be reverted with phosphoethanolamine

Recurrent somatic mutations in ETNK1 (Ethanolamine-Kinase-1) were identified in several myeloid malignancies and are responsible for a reduced enzymatic activity. Here, we demonstrate in primary leukemic cells and in cell lines that mutated ETNK1 causes a significant increase in mitochondrial activi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Fontana, Diletta, Mauri, Mario, Renso, Rossella, Docci, Mattia, Crespiatico, Ilaria, Røst, Lisa M., Jang, Mi, Niro, Antonio, D’Aliberti, Deborah, Massimino, Luca, Bertagna, Mayla, Zambrotta, Giovanni, Bossi, Mario, Citterio, Stefania, Crescenzi, Barbara, Fanelli, Francesca, Cassina, Valeria, Corti, Roberta, Salerno, Domenico, Nardo, Luca, Chinello, Clizia, Mantegazza, Francesco, Mecucci, Cristina, Magni, Fulvio, Cavaletti, Guido, Bruheim, Per, Rea, Delphine, Larsen, Steen, Gambacorti-Passerini, Carlo, Piazza, Rocco
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7684297/
https://ncbi.nlm.nih.gov/pubmed/33230096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19721-w
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