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Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability

Pharmacological interventions for hepatocellular carcinoma (HCC) are hindered by complex factors, and rational combination therapy may be developed to improve therapeutic outcomes. Very recently, we have identified a bioengineered microRNA let-7c-5p (or let-7c) agent as an effective inhibitor agains...

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Foilsithe in:Drug Metab Dispos
Main Authors: Jilek, Joseph L., Tu, Mei-Juan, Zhang, Chao, Yu, Ai-Ming
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2020
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7684025/
https://ncbi.nlm.nih.gov/pubmed/33051247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.000207
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