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Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

TRPC1/4/5 channels are non-specific cation channels implicated in a wide variety of diseases, and TRPC1/4/5 inhibitors have recently entered clinical trials. However, fundamental and translational studies require a better understanding of TRPC1/4/5 channel regulation by endogenous and exogenous fact...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Commun Biol
Hauptverfasser: Wright, David J., Simmons, Katie J., Johnson, Rachel M., Beech, David J., Muench, Stephen P., Bon, Robin S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7683545/
https://ncbi.nlm.nih.gov/pubmed/33230284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01437-8
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