Potent, selective, and subunit‐dependent activation of TRPC5 channels by a xanthine derivative

BACKGROUND AND PURPOSE: The TRPC1, TRPC4, and TRPC5 proteins form homotetrameric or heterotetrameric, calcium‐permeable cation channels that are involved in various disease states. Recent research has yielded specific and potent xanthine‐based TRPC1/4/5 inhibitors. Here, we investigated the possibil...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Minard, Aisling, Bauer, Claudia C., Chuntharpursat‐Bon, Eulashini, Pickles, Isabelle B., Wright, David J., Ludlow, Melanie J., Burnham, Matthew P., Warriner, Stuart L., Beech, David J., Muraki, Katsuhiko, Bon, Robin S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811774/
https://ncbi.nlm.nih.gov/pubmed/31277085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14791
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