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In Vitro and In Vivo Genetic Disease Modeling via NHEJ-Precise Deletions Using CRISPR-Cas9

The development of advanced gene and cell therapies for the treatment of genetic diseases requires reliable animal and cellular models to test their efficacy. Moreover, the availability of the target human primary cells of these therapies is reduced in many diseases. The development of endonucleases...

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Библиографические подробности
Опубликовано в: :Mol Ther Methods Clin Dev
Главные авторы: López-Manzaneda, Sergio, Ojeda-Pérez, Isabel, Zabaleta, Nerea, García-Torralba, Aída, Alberquilla, Omaira, Torres, Raúl, Sánchez-Domínguez, Rebeca, Torella, Laura, Olivier, Emmanuel, Mountford, Joanne, Ramírez, Juan C., Bueren, Juan A., González-Aseguinolaza, Gloria, Segovia, Jose-Carlos
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Gene & Cell Therapy 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7683234/
https://ncbi.nlm.nih.gov/pubmed/33294491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.10.007
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